Wynn With This Just In
Clinical Articles Brought to You by Lexicomp
and Dr. Richard L. Wynn
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The purpose of this column is to keep professionals
informed of recent reports regarding drugs and other events which may
influence dental treatment. These reports will be gleaned from
scientific journals, screened for dissemination, and presented on a
timely basis and with great accuracy.
It is hoped the dental professional will reap
significant benefit from this information, and it will contribute to
superior patient care.
Each month a new article will be published. If you are
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Over-the-counter analgesic use and potential hearing loss
Exploring potential predictors of bisphosphonate-associated osteonecrosis of the jawbone
Guideline update on antibiotic prophylaxis for joint replacement patients (December 2012)
Vitamin D Deficiency and Non-specific Musculoskeletal Pain
Vitamin D - the latest report boosting its potential as an anti-inflammatory in periodontal disease
Bleeding with herbal-containing energy drinks and with ginkgo biloba: from dental and medical reports
Kaiser Permanente Report Details New Findings on Oral Bisphosphonate Treatment
Belviq® and Qsymia™: two new diet drugs approved within weeks of each other. Are there any dental concerns?
Azithromycin (Zithromax®; Z-Pak®) associated with increased risk of cardiovascular death
Bleeding risks in older patients on warfarin and taking antibiotics and antifungals
A comparison of bleeding with and without warfarin or aspirin after single tooth extraction.
Supplement/Natural Products Safety - the Food and Drug Administration's Newly Proposed Guidelines
Three New Reports on Heart Attack Risk: Tooth Scaling Decreases Risk, Periodontal Disease Predicts Type of Risk, Stopping Aspirin Increases Risk
Aspirin for Cardioprotection: Latest Recommendations from the U.S. Preventive Services Task Force
Updating the Management of the Dental Patient at Risk for Osteonecrosis of the Jaw Bone (ONJ) While Taking Bisphosphonates or Denosumab (Prolia®) - Latest Reports from the American Dental Association
Ketorolac Nasal Spray (Sprix®) — The Data Looks Good as a Very Effective Non-Narcotic Acute Pain Reliever after Surgery
Over-the-Counter Ibuprofen and Acetaminophen in Combination are Superior to Each Agent Alone in Treating Postoperative Pain
2,408 Patient Cases of Bisphosphonate-Associated Osteonecrosis of the Jaw Bone: The Most Extensive Review to Date
Rivaroxaban (Xarelto®) & Ticagrelor (Brilinta®): More Blood Thinners Added to the Growing Family
Bevacizumab (Avastin®): Another Drug Associated With Osteonecrosis of the Jaw
Denosumab and Its Association With Osteonecrosis of the Jaw: More Reports
Use of Lexi-Interact to Evaluate Drug Interactions and Bleeding in Patients taking Multiple Medications, including Warfarin, and Undergoing Dental Surgery
Once-Yearly 5 Milligram Zoledronic Acid Intravenous Infusion (Reclast®) for Osteoporosis is Most Likely Not Associated With Osteonecrosis of the Jaw.
A New Study Shows that Ibuprofen (Motrin?) 800 mg Three Times Daily Diminishes the Antiplatelet Effects of Daily Baby Aspirin
FDA Limits Acetaminophen in Prescription Combination Pain Relievers to 325 mg. Also, Dabigatran (Pradaxa®), a New Anticoagulant You Will See in Cardiovascular Patients.
Actiq®, The Sugar-Loaded Opiate Lollipop and the Risk for Tooth Decay
The Latest on the Occurrence of Paresthesia Associated with Local Anesthetics - Reports from 2009 and 2010
Botulinum Toxin, aka Botox®, Dysport®, Myobloc®: Pharmacology 101
Is There an Aspirin Resistance? Not if You Remember to Take Your Daily Aspirin!
A New Class of Drugs Called Anti-RANKL Agents May Be Associated With Osteonecrosis of the Jaw
Twice-a-day Toothbrushing Associated With Decreased Levels of C-reactive Protein and Decrease Risk of Heart Disease.
Two reports on antidepressants: They are the top drug group for drug-related hospital admissions; they have questionable efficacy against mild to moderate forms of mental depression.
Low occurrence of osteonecrosis of the jaw in cancer patients exposed to bisphosphonates and undergoing surgical tooth extractions. Also, few implant failures reported in another study of patients with a history of bisphosphonate therapy.
Recent data on the value of the CTX test as predictive of osteonecrosis of the jaw bone in patients exposed to bisphosphonates.
Mayo Clinic study shows that dental procedures are not a risk factor in prosthetic hip or knee infections. Authors call for reconsideration of administering antibiotics to all patients with prosthetic hip or knee joints who undergo dental treatment.
A New Report: Prevalence of Osteonecrosis of the Jaw in Patients Using Fosamax®-type Drugs is 0.1%
Update on Aspirin Alerts
Statin Users Taking CoQ10 Supplements
Relationship Between C-reactive Protein & Periodontal Disease - Connecting Some of the Dots
Prasugrel (Effient™), A Platelet Aggregation Inhibitor that is the New Kid on the Block Also: FDA Finalizes Device Ruling for Mercury and Dental Amalgam
Update on Oral Bisphosphonate-Associated Osteonecrosis of the Jaw: New Informational Statement by the ADA; Oral Surgery Literature Reiterates Prevalence is Low
Introducing a new drug monograph field, "Effects on Bleeding". Also, antidepressants are associated with increased bleeding.
Premedication in Dental Patients with Joint Replacements
Important Updates from the AAOS and ADA
Aspirin and Heart Attacks
Clopidogrel (Plavix®) as an Antiplatelet Agent - Genetics May Affect Drug Responsiveness
The Safety of OraVerse™ - a Dental Drug that Speeds Up Return to Normal After Soft-tissue Anesthesia
OraVerse™ - A Newly Approved Drug that is Effective in Children in Reversing Soft-tissue Local Anesthesia
OraVerse™ - A Newly Approved Drug That Speeds Up Return to Normal After Soft-tissue Anesthesia
Prevalence rate of necrotic jaw bone in patients taking Fosamax®-type drugs continues to be low. Plus, more on dental implant success in Fosamax patients.
Endocarditis-Causing Bacteria Show Up in the Bloodstream After Toothbrushing
Dental Amalgam, the FDA, and Two Safety Studies in Children
Vitamin D - New Reports Boost Its Potential as an Anti-Inflammatory
Alpha-Lipoic Acid Useful in Treating Burning Mouth Syndrome
High Blood Pressure and Underactive Thyroid Gland (Hypothyroidism)
(Chantix™) is effective in helping smokers quit, but it is
not without problems.
and Dental Implants
Review of the Harvard Fosamax® Study
and Osteonecrosis of the Jaw – Some New and Frequently Asked
Experts Weigh In On Osteonecrosis of the Jaw and Bisphosphonates: A New
Task Force Report
American Heart Association Guidelines for Preventing Heart Disease in
are we with the benefits of aspirin in women?
to the Patient from the ADA on the Issues of: (1) The change in
guidelines for antibiotic prophylaxis; (2) Oral bisphosphonates and
osteonecrosis of the jawbone; (3) The stent patient on aspirin and
Treatment Options in the Management of Osteoporosis
of the Jaw in Cancer After Treatment with Bisphosphonates: More
Information from Australia
Guidelines for the Prevention of Infective Endocarditis - the Bottom
on the Frequency of Oral Bisphosphonate-Associated Osteonecrosis of the
Jaw: A New Report from Australia
Anti-Inflammatory Drug Use in the First Trimester of Pregnancy
Increases the Risk of Congenital Anomalies
Advisory Warning Against the Discontinuation of Dual
Aspirin/Clopidogrel (Plavix®) Antiplatelet Therapy in Patients
with Coronary Artery Stents
(Septocaine®) Formulation with Less Vasoconstrictor Gains FDA
Dosing and Naproxen Use in Patients on Cardioprotective Aspirin
Blunts Aspirin's Cardioprotection. FDA Issues Warning
Hopkins and the Mayo Clinic Speak to the Issue of
Bisphosphonate-Associated Osteonecrotic Jaw Bone (ONJ)
Findings on the Association Between Bisphosphonates and Osteonecrosis
of the Jaw
Boniva and Other Oral Bisphosphonates and Necrotic Jaw Bone
osteonecrotic jawbone - continuing with more reports relative to dental
including alendronate (Fosamax®), and ONJ